NRF2 in age-related musculoskeletal diseases: Role and treatment prospects
The NRF2 pathway is a metabolic- and redox-sensitive signaling axis in which the transcription factor controls the expression of a multitude of genes that enable cells to survive environmental stressors, such as oxidative stress, mainly B6 by inducing the expression of cytoprotective genes.Basal NRF2 levels are maintained under normal physiological